Skip to main content
Logo for Main St. Inn Bed & Breakfast featuring a fleur-de-lis design.
Ste. Genevieve, MO
573-880-7500
Logo for Main St. Inn Bed & Breakfast featuring a fleur-de-lis design.

Welcome to Main St. Inn

Sainte Genevieve's Timeless Treasure

Located in the heart of historic Sainte Genevieve the Main Street Inn Bed and Breakfast has been dedicated to providing exceptional services to guests and visitors for 145 years. A recent renovation has maintained all of the original architectural features while updating the decor and amenities to suit present day expectations.

Cozy bedroom with a bed, two lamps, artwork on the walls, and a decorative rug.

Elegant Historic Rooms​

10 unique guest rooms and suites, each with its own character and private en-suite bathroom. Step back in time while enjoying modern comforts. All rooms feature luxurious bedding, antique furnishings, original artwork, high-speed WiFi, and thoughtful details. Several rooms include king beds, sitting areas, and pet-friendly options.
A cozy dining room features a wooden table set with plates, glasses, and yellow napkins, surrounded by chairs and elegant decor.

Gourmet Breakfast

Wake up to fresh coffee, homemade pastries, seasonal fruit, and a rotating menu of hearty favorites made with local ingredients. Breakfast is served in our beautiful dining room or on the porch when weather permits.
A cozy living room featuring a light gray sofa, decorative pillows, a glass coffee table, and warm lighting from table lamps.

Art & Culture​

The Main Street Inn features an impressive collection of contemporary and regional art, including works by Shepard Fairey, Bryan Haynes, and local artists, plus rare Frank Lloyd Wright Garden Sprites in the courtyard.
A cozy porch featuring a wicker table and chairs, with a patterned rug and green trees in the background.

Relax on the Porch​

Sit and rock in comfortable chairs overlooking historic North Main Street. A perfect place to enjoy your morning coffee, evening wine & cheese reception, or simply watch the world go by.
A smiling woman and man pose together with their arms around each other in a cozy interior setting.

Meet Your Innkeepers

Susan and I (Patrick) bought the historic Main Street Inn in 2016 — the same year we got married — and closed it for a full year to give it a proper renovation. We kept the building's original bones intact but replaced nearly all the furniture and repainted every surface, top to bottom. The goal was simple: preserve the Inn's 19th-century character while quietly updating it with the comfort and amenities today's guests expect.

Susan has practiced internal medicine and pulmonary disease in Ste. Genevieve for more than 30 years. I spent 40 years on the faculty at Loyola University Chicago's Stritch School of Medicine before retiring in 2020. Between the two of us, we've built a life they love in small-town Missouri — one that still leaves plenty of room for travel through Europe, especially trips back to Susan's native Ireland.

Read our full story →

Recent Testimonials

Experience the Difference

4.9 Star Rating with over 160 Reviews
SP Local Guide
★★★★★

“With-in walking distance of most of the historic district. Patrick was very sociable and told great stories of the history. Had great recommendations for restaurants and places to see. Great rooms and very good breakfast served with wonderful stories. Easily get to mainstreet historic & shopping district and some very fine restaurants and ice cream shops. Hosted a happy hour with local delicacies and wine. Served a very fine breakfast that had homemade breads, local trimmings, warm dishes, and yogurt with fresh fruit.”

Shane Poindexter

Local Guide

SK Local Guide
★★★★★

“We spent three relaxing nights back in time. Patrick was an amazing host and I could have listened to the stories and history of Ste Genevieve for hours! The room was beautiful and comfortable. We stayed in the Rendezvous Room and loved having access to the outside for ease of coming and going exploring. It was easy to get to and from shops and restaurants walking. Breakfast was filling and delicious and we felt so pampered. Barney, the hospitality manager, was the sweetest dog and enjoyed the attention. Wine and cheese in the afternoon led to interesting conversations and new friends. This bed and breakfast experience was the perfect balance of interaction and alone relaxing time. It felt like we joined long-time friends for a visit. The high-quality antique mall was a must and Stella and Me Cafe was delicious! And don’t forget to ask Patrick about the penguins!”

Shelly Keefe

Local Guide

SK Local Guide
★★★★★

“We spent three relaxing nights back in time. Patrick was an amazing host and I could have listened to the stories and history of Ste Genevieve for hours! The room was beautiful and comfortable. We stayed in the Rendezvous Room and loved having access to the outside for ease of coming and going exploring. It was easy to get to and from shops and restaurants walking. Breakfast was filling and delicious and we felt so pampered. Barney, the hospitality manager, was the sweetest dog and enjoyed the attention. Wine and cheese in the afternoon led to interesting conversations and new friends. This bed and breakfast experience was the perfect balance of interaction and alone relaxing time. It felt like we joined long-time friends for a visit. The high-quality antique mall was a must and Stella and Me Cafe was delicious! And don’t forget to ask Patrick about the penguins!”

Shelly Keefe

Local Guide

AC Local Guide
★★★★★

“We had a truly beautiful weekend stay at Main Street Inn B&B in Ste. Genevieve, MO. From the moment we arrived, everything felt warm, welcoming, and thoughtfully considered. The hosts, Patrick and Susan, were wonderful—gracious, attentive, and genuinely hospitable—and Barney the dog was an added delight. The accommodation itself was excellent: immaculate throughout, with a clear sense of care and attention to detail in every space. The interiors are stunning, with beautiful antiques, plush hand-woven Persian-style rugs, and tasteful artwork all knit together with a modern flair that gives the whole house a refined but comfortable atmosphere. Small thoughtful touches throughout the stay made it feel especially comfortable and personal. Breakfast each morning was wonderful—fresh, generous, and beautifully prepared from ingredients many of which were locally sourced, sometimes as local as the garden out back! The evening wine and cheese hour was a highlight and a lovely way to unwind and meet other guests. The other visitors were also part of what made the stay memorable—a self-selecting group of interesting, friendly, and engaging people that added to the overall experience without ever feeling forced. A genuinely special place to stay - we hope to do so again and can easily recommend to others without hesitation.”

Amy Carr

Local Guide

AC Local Guide
★★★★★

“We had a truly beautiful weekend stay at Main Street Inn B&B in Ste. Genevieve, MO. From the moment we arrived, everything felt warm, welcoming, and thoughtfully considered. The hosts, Patrick and Susan, were wonderful—gracious, attentive, and genuinely hospitable—and Barney the dog was an added delight. The accommodation itself was excellent: immaculate throughout, with a clear sense of care and attention to detail in every space. The interiors are stunning, with beautiful antiques, plush hand-woven Persian-style rugs, and tasteful artwork all knit together with a modern flair that gives the whole house a refined but comfortable atmosphere. Small thoughtful touches throughout the stay made it feel especially comfortable and personal. Breakfast each morning was wonderful—fresh, generous, and beautifully prepared from ingredients many of which were locally sourced, sometimes as local as the garden out back! The evening wine and cheese hour was a highlight and a lovely way to unwind and meet other guests. The other visitors were also part of what made the stay memorable—a self-selecting group of interesting, friendly, and engaging people that added to the overall experience without ever feeling forced. A genuinely special place to stay - we hope to do so again and can easily recommend to others without hesitation.”

Amy Carr

Local Guide

MJ Recent Visitor
★★★★★

“Some places simply give you a bed for the night. The Main Street Inn in Ste. Genevieve Inn gives you an experience you’ll remember long after you’ve left. From the moment we arrived, we felt genuinely welcomed. The inn is immaculate, comfortable, and filled with thoughtful touches that make it feel less like a hotel and more like the home of dear friends who happen to have impeccable taste. Susan’s eye for design is evident everywhere you look. Every room and every detail feels intentional, creating a warm, elegant atmosphere without ever losing its cozy charm. Then there are Patrick’s delightful penguins! They aren’t just decorations. They bring a sense of whimsy, personality, and smiles around every corner. By the end of our stay, we found ourselves looking forward to spotting the next one. They perfectly reflect the fun spirit of the inn and its owners. The location is ideal for exploring beautiful, historic Ste. Genevieve, but honestly, the inn itself became one of our favorite parts of the visit. Our stay here has been one of the highlights of our Great River Road adventure. We arrived expecting a wonderful place to spend the night and left feeling like we’d discovered a hidden treasure. Patrick and Susan have created something truly special, blending gracious hospitality, beautiful design, comfort, and just the right touch of playful charm. We will absolutely be back, and we wholeheartedly recommend the Main Street Inn in Ste.. Genevieve to anyone looking for more than just a place to stay. This is the kind of place that stays with you. Five enthusiastic stars! P.S. Breakfast was a wonderful and the Director of Hospitality, Barney, is always glad to greet you!”

Melissa Jansen

Recent Visitor

MJ Recent Visitor
★★★★★

“Some places simply give you a bed for the night. The Main Street Inn in Ste. Genevieve Inn gives you an experience you’ll remember long after you’ve left. From the moment we arrived, we felt genuinely welcomed. The inn is immaculate, comfortable, and filled with thoughtful touches that make it feel less like a hotel and more like the home of dear friends who happen to have impeccable taste. Susan’s eye for design is evident everywhere you look. Every room and every detail feels intentional, creating a warm, elegant atmosphere without ever losing its cozy charm. Then there are Patrick’s delightful penguins! They aren’t just decorations. They bring a sense of whimsy, personality, and smiles around every corner. By the end of our stay, we found ourselves looking forward to spotting the next one. They perfectly reflect the fun spirit of the inn and its owners. The location is ideal for exploring beautiful, historic Ste. Genevieve, but honestly, the inn itself became one of our favorite parts of the visit. Our stay here has been one of the highlights of our Great River Road adventure. We arrived expecting a wonderful place to spend the night and left feeling like we’d discovered a hidden treasure. Patrick and Susan have created something truly special, blending gracious hospitality, beautiful design, comfort, and just the right touch of playful charm. We will absolutely be back, and we wholeheartedly recommend the Main Street Inn in Ste.. Genevieve to anyone looking for more than just a place to stay. This is the kind of place that stays with you. Five enthusiastic stars! P.S. Breakfast was a wonderful and the Director of Hospitality, Barney, is always glad to greet you!”

Melissa Jansen

Recent Visitor

SP Local Guide
★★★★★

“With-in walking distance of most of the historic district. Patrick was very sociable and told great stories of the history. Had great recommendations for restaurants and places to see. Great rooms and very good breakfast served with wonderful stories. Easily get to mainstreet historic & shopping district and some very fine restaurants and ice cream shops. Hosted a happy hour with local delicacies and wine. Served a very fine breakfast that had homemade breads, local trimmings, warm dishes, and yogurt with fresh fruit.”

Shane Poindexter

Local Guide

Historical

Ste. Genevieve

A historic destination and vibrant community, Ste. Genevieve is recognized as the oldest permanent settlement in the state of Missouri. French colonists living in the Illinois territory on the east side of the Mississippi crossed the river in 1735 and built homes along the fertile river bottom. Many of these homes from the late 1700s have been preserved. The National Park Service recognized the significance of these structures and have established the Saint Genevieve National Historic Park. All of these homes are within a short walking distance of our Inn.

A dog walks past a wooden bridge in front of a house surrounded by trees.
A snow-covered landscape features a vintage house amid bare trees against a colorful sunset sky.
A historic house with a unique roof design surrounded by parked cars and a wooden fence under a clear blue sky.
A crowd sits in front of a historic house while observing a presentation on its porch.

Photo Gallery

A spacious dining room featuring a large wooden table, elegant chairs, and a decorative floral centerpiece.
Sign for Main St. Inn Bed & Breakfast with flowering plants and a street view.
A penguin stands at the base of a staircase, partially obscured by a wall.
A penguin statue stands beside colorful flowers in front of a bed and breakfast sign.
A dog stands on a porch surrounded by colorful flower pots in bright sunlight.
Historic two-story brick inn with a front porch and lush greenery.
A stylish bathroom featuring a jacuzzi, fireplace, and chandelier.
A serene bedroom featuring a queen-sized bed, two lamps, and framed artwork on light blue walls.
A cozy bedroom featuring a blue bedspread, two blue armchairs, and a mix of stone and brick walls, along with artwork and bedside lamps.
A spacious dining room featuring a large wooden table, elegant chairs, and a decorative floral centerpiece.
Historic two-story brick inn with a front porch and lush greenery.
A penguin stands at the base of a staircase, partially obscured by a wall.
A dog stands on a porch surrounded by colorful flower pots in bright sunlight.
A serene bedroom featuring a queen-sized bed, two lamps, and framed artwork on light blue walls.
A cozy bedroom featuring a blue bedspread, two blue armchairs, and a mix of stone and brick walls, along with artwork and bedside lamps.
Sign for Main St. Inn Bed & Breakfast with flowering plants and a street view.
A stylish bathroom featuring a jacuzzi, fireplace, and chandelier.
A penguin statue stands beside colorful flowers in front of a bed and breakfast sign.
A spacious dining room featuring a large wooden table, elegant chairs, and a decorative floral centerpiece.
A stylish bathroom featuring a jacuzzi, fireplace, and chandelier.
A penguin statue stands beside colorful flowers in front of a bed and breakfast sign.
A dog stands on a porch surrounded by colorful flower pots in bright sunlight.
A cozy bedroom featuring a blue bedspread, two blue armchairs, and a mix of stone and brick walls, along with artwork and bedside lamps.
Sign for Main St. Inn Bed & Breakfast with flowering plants and a street view.
A serene bedroom featuring a queen-sized bed, two lamps, and framed artwork on light blue walls.
Historic two-story brick inn with a front porch and lush greenery.
A penguin stands at the base of a staircase, partially obscured by a wall.