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Ste. Genevieve, MO
573-880-7500
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  • Historic two-story brick inn with a front porch and lush greenery.

Welcome to Main St. Inn

Sainte Genevieve's Timeless Treasure

Located in the heart of historic Sainte Genevieve the Main Street Inn Bed and Breakfast has been dedicated to providing exceptional services to guests and visitors for 145 years. A recent renovation has maintained all of the original architectural features while updating the decor and amenities to suit present day expectations.

Cozy bedroom with a bed, two lamps, artwork on the walls, and a decorative rug.

Amenities

Our guest experience starts with a wine and cheese reception each evening. A full course inspired breakfast is served each day. All guest rooms have en suite bathrooms, WiFi, original art and sculptures and antique Persian carpets from the owners' private collection. An extensive library and art collection are found in the parlors on the main floor.

A two-story brown house with a porch and green doors, surrounded by sparse vegetation and a cloudy sky.

The Lewis Delcommune House

Our Inn now consists now of 10 guest rooms and suites and we have recently added a nearby 1821 log home. The Lewis Delcommune house, built circa 1821, is a one bedroom one bath newly updated historic home.

Historical

Ste Genevieve

A historic destination and vibrant community, Ste Genevieve is recognized as the oldest permanent settlement in the state of Missouri. French colonists living in the Illinois territory on the east side of the Mississippi crossed the river in 1735 and built homes along the fertile river bottom. Many of these homes from the late 1700s have been preserved. The National Park Service recognized the significance of these structures and have established the Saint Genevieve National Historic Park. All of these homes are within a short walking distance of our Inn.

A dog walks past a wooden bridge in front of a house surrounded by trees.
A snow-covered landscape features a vintage house amid bare trees against a colorful sunset sky.
A historic yellow house surrounded by trees and autumn foliage.
A historic house with a unique roof design surrounded by parked cars and a wooden fence under a clear blue sky.

Photo Gallery

A spacious dining room featuring a large wooden table, elegant chairs, and a decorative floral centerpiece.
Sign for Main St. Inn Bed & Breakfast with flowering plants and a street view.
A penguin stands at the base of a staircase, partially obscured by a wall.
A penguin statue stands beside colorful flowers in front of a bed and breakfast sign.
A dog stands on a porch surrounded by colorful flower pots in bright sunlight.
Historic two-story brick inn with a front porch and lush greenery.
A stylish bathroom featuring a jacuzzi, fireplace, and chandelier.
A serene bedroom featuring a queen-sized bed, two lamps, and framed artwork on light blue walls.
A cozy bedroom featuring a blue bedspread, two blue armchairs, and a mix of stone and brick walls, along with artwork and bedside lamps.
A spacious dining room featuring a large wooden table, elegant chairs, and a decorative floral centerpiece.
Historic two-story brick inn with a front porch and lush greenery.
A penguin stands at the base of a staircase, partially obscured by a wall.
A dog stands on a porch surrounded by colorful flower pots in bright sunlight.
A serene bedroom featuring a queen-sized bed, two lamps, and framed artwork on light blue walls.
A cozy bedroom featuring a blue bedspread, two blue armchairs, and a mix of stone and brick walls, along with artwork and bedside lamps.
Sign for Main St. Inn Bed & Breakfast with flowering plants and a street view.
A stylish bathroom featuring a jacuzzi, fireplace, and chandelier.
A penguin statue stands beside colorful flowers in front of a bed and breakfast sign.
A spacious dining room featuring a large wooden table, elegant chairs, and a decorative floral centerpiece.
A stylish bathroom featuring a jacuzzi, fireplace, and chandelier.
A penguin statue stands beside colorful flowers in front of a bed and breakfast sign.
A dog stands on a porch surrounded by colorful flower pots in bright sunlight.
A cozy bedroom featuring a blue bedspread, two blue armchairs, and a mix of stone and brick walls, along with artwork and bedside lamps.
Sign for Main St. Inn Bed & Breakfast with flowering plants and a street view.
A serene bedroom featuring a queen-sized bed, two lamps, and framed artwork on light blue walls.
Historic two-story brick inn with a front porch and lush greenery.
A penguin stands at the base of a staircase, partially obscured by a wall.